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Anselmo AC, Gokarn Y, Mitragotri S

For example, p53 promotes cell survival by inhibiting ferroptosis in the absence of cysteine, suggesting an association between p53 and cysteine metabolism in ferroptosis (Tarangelo et al., 2018)

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Sometimes termed Phase III reactions, these usually consist of the removal of glutamyl and glycinyl groups and acetylation of cysteine to produce mercapturic acid or an N-acetylcysteine conjugate which can then be excreted, usually via bile or urine (Figure 2)